Clinical efficacy of amiodarone as an antiarrhythmic agent
Identifieur interne : 000D72 ( Main/Corpus ); précédent : 000D71; suivant : 000D73Clinical efficacy of amiodarone as an antiarrhythmic agent
Auteurs : Mauricio B. Rosenbaum ; Pablo A. Chiale ; M. Susana Halpern ; Gerardo J. Nau ; Julio Przybylski ; Raúl J. Levi ; Julio O. Lázzari ; Marcelo V. ElizariSource :
- The American Journal of Cardiology [ 0002-9149 ] ; 1976.
Abstract
Amiodarone, administered orally in doses of 200 to 600 mg/day, was remarkably effective in the treatment and prevention of a wide variety of atrial and ventricular arrhythmias. Total suppression and control was provided in 98 (92.4 percent) of 106 patients with supraventricular arrhythmias and in 119 (82 percent) of 145 patients with ventricular arrhythmias. The rates of total control of the arrhythmia were: 96.6 percent in 30 patients with recurrent atrial flutter or fibrillation, 96.6 percent in 59 patients with repetitive supraventricular tachycardia, 100 percent in 27 patients with Wolff-Parkinson-White syndrome and 77.2 percent in 44 patients with recurrent ventricular tachycardia unsuccessfully treated with other drugs. Excellent results were obtained in 6 of 8 patients with repetitive ventricular tachycardia and ventricular fibrillation related to postinfarction ventricular aneurysm and in 12 of 14 patients with ventricular extrasystoles and ventricular tachycardia related to Chagasic myocarditis. Amiodarone proved safe in patients with severe congestive heart failure and severe myocardial damage. Its clinical efficacy was related to its electrophysiologic properties and to two unique properties: its wide safety margin and its cumulative effect. The latter liberates patients from a rigid hourly schedule and provides for continuous antiarrhythmic control, days and even weeks after treatment is discontinued.
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DOI: 10.1016/0002-9149(76)90807-9
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Susana Halpern</name><affiliation><mods:affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Nau, Gerardo J" sort="Nau, Gerardo J" uniqKey="Nau G" first="Gerardo J." last="Nau">Gerardo J. Nau</name><affiliation><mods:affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Przybylski, Julio" sort="Przybylski, Julio" uniqKey="Przybylski J" first="Julio" last="Przybylski">Julio Przybylski</name><affiliation><mods:affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Levi, Raul J" sort="Levi, Raul J" uniqKey="Levi R" first="Raúl J." last="Levi">Raúl J. Levi</name><affiliation><mods:affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Lazzari, Julio O" sort="Lazzari, Julio O" uniqKey="Lazzari J" first="Julio O." last="Lázzari">Julio O. Lázzari</name><affiliation><mods:affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Elizari, Marcelo V" sort="Elizari, Marcelo V" uniqKey="Elizari M" first="Marcelo V." last="Elizari">Marcelo V. 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Rosenbaum</name><affiliation><mods:affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Chiale, Pablo A" sort="Chiale, Pablo A" uniqKey="Chiale P" first="Pablo A." last="Chiale">Pablo A. Chiale</name><affiliation><mods:affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Halpern, M Susana" sort="Halpern, M Susana" uniqKey="Halpern M" first="M. Susana" last="Halpern">M. Susana Halpern</name><affiliation><mods:affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Nau, Gerardo J" sort="Nau, Gerardo J" uniqKey="Nau G" first="Gerardo J." last="Nau">Gerardo J. Nau</name><affiliation><mods:affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Przybylski, Julio" sort="Przybylski, Julio" uniqKey="Przybylski J" first="Julio" last="Przybylski">Julio Przybylski</name><affiliation><mods:affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Levi, Raul J" sort="Levi, Raul J" uniqKey="Levi R" first="Raúl J." last="Levi">Raúl J. Levi</name><affiliation><mods:affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Lazzari, Julio O" sort="Lazzari, Julio O" uniqKey="Lazzari J" first="Julio O." last="Lázzari">Julio O. Lázzari</name><affiliation><mods:affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Elizari, Marcelo V" sort="Elizari, Marcelo V" uniqKey="Elizari M" first="Marcelo V." last="Elizari">Marcelo V. Elizari</name><affiliation><mods:affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">The American Journal of Cardiology</title><title level="j" type="abbrev">AJC</title><idno type="ISSN">0002-9149</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1976">1976</date><biblScope unit="volume">38</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="934">934</biblScope><biblScope unit="page" to="944">944</biblScope></imprint><idno type="ISSN">0002-9149</idno></series><idno type="istex">C89A7A24AF71879FBE9CD4BD8F965EDC8BF028BE</idno><idno type="DOI">10.1016/0002-9149(76)90807-9</idno><idno type="PII">0002-9149(76)90807-9</idno><idno type="ArticleID">76908079</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-9149</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Amiodarone, administered orally in doses of 200 to 600 mg/day, was remarkably effective in the treatment and prevention of a wide variety of atrial and ventricular arrhythmias. Total suppression and control was provided in 98 (92.4 percent) of 106 patients with supraventricular arrhythmias and in 119 (82 percent) of 145 patients with ventricular arrhythmias. The rates of total control of the arrhythmia were: 96.6 percent in 30 patients with recurrent atrial flutter or fibrillation, 96.6 percent in 59 patients with repetitive supraventricular tachycardia, 100 percent in 27 patients with Wolff-Parkinson-White syndrome and 77.2 percent in 44 patients with recurrent ventricular tachycardia unsuccessfully treated with other drugs. Excellent results were obtained in 6 of 8 patients with repetitive ventricular tachycardia and ventricular fibrillation related to postinfarction ventricular aneurysm and in 12 of 14 patients with ventricular extrasystoles and ventricular tachycardia related to Chagasic myocarditis. Amiodarone proved safe in patients with severe congestive heart failure and severe myocardial damage. Its clinical efficacy was related to its electrophysiologic properties and to two unique properties: its wide safety margin and its cumulative effect. The latter liberates patients from a rigid hourly schedule and provides for continuous antiarrhythmic control, days and even weeks after treatment is discontinued.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Mauricio B. Rosenbaum MD, FACC</name><affiliations><json:string>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</json:string></affiliations></json:item><json:item><name>Pablo A. Chiale MD</name><affiliations><json:string>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</json:string></affiliations></json:item><json:item><name>M.Susana Halpern MD</name><affiliations><json:string>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</json:string></affiliations></json:item><json:item><name>Gerardo J. Nau MD</name><affiliations><json:string>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</json:string></affiliations></json:item><json:item><name>Julio Przybylski MD</name><affiliations><json:string>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</json:string></affiliations></json:item><json:item><name>Raúl J. Levi MD</name><affiliations><json:string>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</json:string></affiliations></json:item><json:item><name>Julio O. Lázzari MD</name><affiliations><json:string>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</json:string></affiliations></json:item><json:item><name>Marcelo V. Elizari MD, FACC</name><affiliations><json:string>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</json:string></affiliations></json:item></author><articleId><json:string>76908079</json:string></articleId><language><json:string>eng</json:string></language><abstract>Amiodarone, administered orally in doses of 200 to 600 mg/day, was remarkably effective in the treatment and prevention of a wide variety of atrial and ventricular arrhythmias. Total suppression and control was provided in 98 (92.4 percent) of 106 patients with supraventricular arrhythmias and in 119 (82 percent) of 145 patients with ventricular arrhythmias. The rates of total control of the arrhythmia were: 96.6 percent in 30 patients with recurrent atrial flutter or fibrillation, 96.6 percent in 59 patients with repetitive supraventricular tachycardia, 100 percent in 27 patients with Wolff-Parkinson-White syndrome and 77.2 percent in 44 patients with recurrent ventricular tachycardia unsuccessfully treated with other drugs. Excellent results were obtained in 6 of 8 patients with repetitive ventricular tachycardia and ventricular fibrillation related to postinfarction ventricular aneurysm and in 12 of 14 patients with ventricular extrasystoles and ventricular tachycardia related to Chagasic myocarditis. Amiodarone proved safe in patients with severe congestive heart failure and severe myocardial damage. Its clinical efficacy was related to its electrophysiologic properties and to two unique properties: its wide safety margin and its cumulative effect. The latter liberates patients from a rigid hourly schedule and provides for continuous antiarrhythmic control, days and even weeks after treatment is discontinued.</abstract><qualityIndicators><score>7.424</score><pdfVersion>1.2</pdfVersion><pdfPageSize>612 x 828 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1436</abstractCharCount><pdfWordCount>6429</pdfWordCount><pdfCharCount>46230</pdfCharCount><pdfPageCount>11</pdfPageCount><abstractWordCount>202</abstractWordCount></qualityIndicators><title>Clinical efficacy of amiodarone as an antiarrhythmic agent</title><pii><json:string>0002-9149(76)90807-9</json:string></pii><genre><json:string>brief communication</json:string></genre><host><volume>38</volume><pii><json:string>S0002-9149(00)X0596-6</json:string></pii><pages><last>944</last><first>934</first></pages><issn><json:string>0002-9149</json:string></issn><issue>7</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>The American Journal of Cardiology</title><publicationDate>1976</publicationDate></host><publicationDate>1976</publicationDate><copyrightDate>1976</copyrightDate><doi><json:string>10.1016/0002-9149(76)90807-9</json:string></doi><id>C89A7A24AF71879FBE9CD4BD8F965EDC8BF028BE</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/C89A7A24AF71879FBE9CD4BD8F965EDC8BF028BE/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/C89A7A24AF71879FBE9CD4BD8F965EDC8BF028BE/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/C89A7A24AF71879FBE9CD4BD8F965EDC8BF028BE/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/C89A7A24AF71879FBE9CD4BD8F965EDC8BF028BE/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Clinical efficacy of amiodarone as an antiarrhythmic agent</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1976</date></publicationStmt><notesStmt><note>This study was supported in part by the Comisión para el Estudio Integral de la Enfermedad de Chagas and by the Fundación de Investigaciones Cardiológicas Einthoven, Buenos Aires, Argentina.</note><note type="content">Section title: Report on therapy</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Clinical efficacy of amiodarone as an antiarrhythmic agent</title><author><persName><forename type="first">Mauricio B.</forename><surname>Rosenbaum</surname></persName><roleName type="degree">MD, FACC</roleName><note type="biography">Address for reprints: Mauricio B. Rosenbaum, MD, Rivadavia 3820 P.B. “A,” Buenos Aires, Argentina.</note><affiliation>Address for reprints: Mauricio B. Rosenbaum, MD, Rivadavia 3820 P.B. “A,” Buenos Aires, Argentina.</affiliation><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation></author><author><persName><forename type="first">Pablo A.</forename><surname>Chiale</surname></persName><roleName type="degree">MD</roleName><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation></author><author><persName><forename type="first">M.Susana</forename><surname>Halpern</surname></persName><roleName type="degree">MD</roleName><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation></author><author><persName><forename type="first">Gerardo J.</forename><surname>Nau</surname></persName><roleName type="degree">MD</roleName><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation></author><author><persName><forename type="first">Julio</forename><surname>Przybylski</surname></persName><roleName type="degree">MD</roleName><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation></author><author><persName><forename type="first">Raúl J.</forename><surname>Levi</surname></persName><roleName type="degree">MD</roleName><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation></author><author><persName><forename type="first">Julio O.</forename><surname>Lázzari</surname></persName><roleName type="degree">MD</roleName><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation></author><author><persName><forename type="first">Marcelo V.</forename><surname>Elizari</surname></persName><roleName type="degree">MD, FACC</roleName><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation></author></analytic><monogr><title level="j">The American Journal of Cardiology</title><title level="j" type="abbrev">AJC</title><idno type="pISSN">0002-9149</idno><idno type="PII">S0002-9149(00)X0596-6</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1976"></date><biblScope unit="volume">38</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="934">934</biblScope><biblScope unit="page" to="944">944</biblScope></imprint></monogr><idno type="istex">C89A7A24AF71879FBE9CD4BD8F965EDC8BF028BE</idno><idno type="DOI">10.1016/0002-9149(76)90807-9</idno><idno type="PII">0002-9149(76)90807-9</idno><idno type="ArticleID">76908079</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1976</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Amiodarone, administered orally in doses of 200 to 600 mg/day, was remarkably effective in the treatment and prevention of a wide variety of atrial and ventricular arrhythmias. Total suppression and control was provided in 98 (92.4 percent) of 106 patients with supraventricular arrhythmias and in 119 (82 percent) of 145 patients with ventricular arrhythmias. The rates of total control of the arrhythmia were: 96.6 percent in 30 patients with recurrent atrial flutter or fibrillation, 96.6 percent in 59 patients with repetitive supraventricular tachycardia, 100 percent in 27 patients with Wolff-Parkinson-White syndrome and 77.2 percent in 44 patients with recurrent ventricular tachycardia unsuccessfully treated with other drugs. Excellent results were obtained in 6 of 8 patients with repetitive ventricular tachycardia and ventricular fibrillation related to postinfarction ventricular aneurysm and in 12 of 14 patients with ventricular extrasystoles and ventricular tachycardia related to Chagasic myocarditis. Amiodarone proved safe in patients with severe congestive heart failure and severe myocardial damage. Its clinical efficacy was related to its electrophysiologic properties and to two unique properties: its wide safety margin and its cumulative effect. The latter liberates patients from a rigid hourly schedule and provides for continuous antiarrhythmic control, days and even weeks after treatment is discontinued.</p></abstract></profileDesc><revisionDesc><change when="1976-07-07">Registration</change><change when="1976-07-07">Modified</change><change when="1976">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="sco" xml:lang="en"><item-info><jid>AJC</jid><aid>76908079</aid><ce:pii>0002-9149(76)90807-9</ce:pii><ce:doi>10.1016/0002-9149(76)90807-9</ce:doi><ce:copyright type="unknown" year="1976"></ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>This study was supported in part by the Comisión para el Estudio Integral de la Enfermedad de Chagas and by the Fundación de Investigaciones Cardiológicas Einthoven, Buenos Aires, Argentina.</ce:note-para></ce:article-footnote><ce:dochead><ce:textfn>Report on therapy</ce:textfn></ce:dochead><ce:title>Clinical efficacy of amiodarone as an antiarrhythmic agent</ce:title><ce:author-group><ce:author><ce:given-name>Mauricio B.</ce:given-name><ce:surname>Rosenbaum</ce:surname><ce:degrees>MD, FACC</ce:degrees><ce:cross-ref refid="COR1"><ce:sup loc="post">∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Pablo A.</ce:given-name><ce:surname>Chiale</ce:surname><ce:degrees>MD</ce:degrees></ce:author><ce:author><ce:given-name>M.Susana</ce:given-name><ce:surname>Halpern</ce:surname><ce:degrees>MD</ce:degrees></ce:author><ce:author><ce:given-name>Gerardo J.</ce:given-name><ce:surname>Nau</ce:surname><ce:degrees>MD</ce:degrees></ce:author><ce:author><ce:given-name>Julio</ce:given-name><ce:surname>Przybylski</ce:surname><ce:degrees>MD</ce:degrees></ce:author><ce:author><ce:given-name>Raúl J.</ce:given-name><ce:surname>Levi</ce:surname><ce:degrees>MD</ce:degrees></ce:author><ce:author><ce:given-name>Julio O.</ce:given-name><ce:surname>Lázzari</ce:surname><ce:degrees>MD</ce:degrees></ce:author><ce:author><ce:given-name>Marcelo V.</ce:given-name><ce:surname>Elizari</ce:surname><ce:degrees>MD, FACC</ce:degrees></ce:author><ce:affiliation><ce:textfn>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Address for reprints: Mauricio B. Rosenbaum, MD, Rivadavia 3820 P.B. “A,” Buenos Aires, Argentina.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="26" month="3" year="1976"></ce:date-received><ce:date-revised day="7" month="7" year="1976"></ce:date-revised><ce:date-accepted day="7" month="7" year="1976"></ce:date-accepted><ce:abstract class="author"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para view="all" id="simple-para.0010">Amiodarone, administered orally in doses of 200 to 600 mg/day, was remarkably effective in the treatment and prevention of a wide variety of atrial and ventricular arrhythmias. Total suppression and control was provided in 98 (92.4 percent) of 106 patients with supraventricular arrhythmias and in 119 (82 percent) of 145 patients with ventricular arrhythmias. The rates of total control of the arrhythmia were: 96.6 percent in 30 patients with recurrent atrial flutter or fibrillation, 96.6 percent in 59 patients with repetitive supraventricular tachycardia, 100 percent in 27 patients with Wolff-Parkinson-White syndrome and 77.2 percent in 44 patients with recurrent ventricular tachycardia unsuccessfully treated with other drugs. Excellent results were obtained in 6 of 8 patients with repetitive ventricular tachycardia and ventricular fibrillation related to postinfarction ventricular aneurysm and in 12 of 14 patients with ventricular extrasystoles and ventricular tachycardia related to Chagasic myocarditis. Amiodarone proved safe in patients with severe congestive heart failure and severe myocardial damage. Its clinical efficacy was related to its electrophysiologic properties and to two unique properties: its wide safety margin and its cumulative effect. The latter liberates patients from a rigid hourly schedule and provides for continuous antiarrhythmic control, days and even weeks after treatment is discontinued.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Clinical efficacy of amiodarone as an antiarrhythmic agent</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Clinical efficacy of amiodarone as an antiarrhythmic agent</title></titleInfo><name type="personal"><namePart type="given">Mauricio B.</namePart><namePart type="family">Rosenbaum</namePart><namePart type="termsOfAddress">MD, FACC</namePart><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation><description>Address for reprints: Mauricio B. Rosenbaum, MD, Rivadavia 3820 P.B. “A,” Buenos Aires, Argentina.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pablo A.</namePart><namePart type="family">Chiale</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.Susana</namePart><namePart type="family">Halpern</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gerardo J.</namePart><namePart type="family">Nau</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Julio</namePart><namePart type="family">Przybylski</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Raúl J.</namePart><namePart type="family">Levi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Julio O.</namePart><namePart type="family">Lázzari</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marcelo V.</namePart><namePart type="family">Elizari</namePart><namePart type="termsOfAddress">MD, FACC</namePart><affiliation>From the Service of Cardiology of Ramos Mejia Hospital, Urquiza 609, Buenos Aires, Argentina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief communication" displayLabel="Short communication"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1976</dateIssued><dateValid encoding="w3cdtf">1976-07-07</dateValid><dateModified encoding="w3cdtf">1976-07-07</dateModified><copyrightDate encoding="w3cdtf">1976</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Amiodarone, administered orally in doses of 200 to 600 mg/day, was remarkably effective in the treatment and prevention of a wide variety of atrial and ventricular arrhythmias. Total suppression and control was provided in 98 (92.4 percent) of 106 patients with supraventricular arrhythmias and in 119 (82 percent) of 145 patients with ventricular arrhythmias. The rates of total control of the arrhythmia were: 96.6 percent in 30 patients with recurrent atrial flutter or fibrillation, 96.6 percent in 59 patients with repetitive supraventricular tachycardia, 100 percent in 27 patients with Wolff-Parkinson-White syndrome and 77.2 percent in 44 patients with recurrent ventricular tachycardia unsuccessfully treated with other drugs. Excellent results were obtained in 6 of 8 patients with repetitive ventricular tachycardia and ventricular fibrillation related to postinfarction ventricular aneurysm and in 12 of 14 patients with ventricular extrasystoles and ventricular tachycardia related to Chagasic myocarditis. Amiodarone proved safe in patients with severe congestive heart failure and severe myocardial damage. Its clinical efficacy was related to its electrophysiologic properties and to two unique properties: its wide safety margin and its cumulative effect. The latter liberates patients from a rigid hourly schedule and provides for continuous antiarrhythmic control, days and even weeks after treatment is discontinued.</abstract><note>This study was supported in part by the Comisión para el Estudio Integral de la Enfermedad de Chagas and by the Fundación de Investigaciones Cardiológicas Einthoven, Buenos Aires, Argentina.</note><note type="content">Section title: Report on therapy</note><relatedItem type="host"><titleInfo><title>The American Journal of Cardiology</title></titleInfo><titleInfo type="abbreviated"><title>AJC</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">197612</dateIssued></originInfo><identifier type="ISSN">0002-9149</identifier><identifier type="PII">S0002-9149(00)X0596-6</identifier><part><date>197612</date><detail type="volume"><number>38</number><caption>vol.</caption></detail><detail type="issue"><number>7</number><caption>no.</caption></detail><extent unit="issue pages"><start>A2</start><end>A40</end></extent><extent unit="issue pages"><start>A45</start><end>A58</end></extent><extent unit="issue pages"><start>A59</start><end>A68</end></extent><extent unit="issue pages"><start>A69</start><end>A91</end></extent><extent unit="issue pages"><start>831</start><end>980</end></extent><extent unit="pages"><start>934</start><end>944</end></extent></part></relatedItem><identifier type="istex">C89A7A24AF71879FBE9CD4BD8F965EDC8BF028BE</identifier><identifier type="DOI">10.1016/0002-9149(76)90807-9</identifier><identifier type="PII">0002-9149(76)90807-9</identifier><identifier type="ArticleID">76908079</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:refBibTEI uri="https://api.istex.fr/document/C89A7A24AF71879FBE9CD4BD8F965EDC8BF028BE/enrichments/refBib"><teiHeader></teiHeader><text><front></front><body></body><back><listBibl><biblStruct><analytic><title level="a" type="main">Control of tachyar-rhythmias associated with Wolff-Parkinson-White syndrome by amiodarone hydrochloride Charlier R: Cardiac actions in the dog of a new antagonist of ad-renergic excitation which does not produce competitive blockade of adrenoceptors</title><author><persName><forename type="first">Rosenbaum</forename><forename type="middle">Mb Pa</forename><surname>Chiale</surname></persName></author><author><persName><forename type="first">Ryba</forename><forename type="middle">D</forename></persName></author></analytic><monogr><title level="j">Am J Cardiol Br J Pharmacol</title><imprint><biblScope unit="volume">34</biblScope><biblScope unit="issue">39</biblScope><biblScope unit="page" from="215" to="223668"></biblScope><date type="published" when="1970"></date></imprint></monogr></biblStruct><biblStruct><analytic><title level="a" type="main">Effects of amiodarone on thyroid function in patients with ischaemic heart disease</title><author><persName><forename type="middle">Da</forename><surname>Pritchard</surname></persName></author><author><persName><surname>Singh</surname></persName></author><author><persName><surname>Bn</surname></persName></author><author><persName><surname>Hurley</surname></persName></author><author><persName><surname>Pj</surname></persName></author></analytic><monogr><title level="m">Rosenbaum MB: Chagasic myocardiopathy</title><imprint><date type="published" when="1964"></date><biblScope unit="page" from="856" to="860199"></biblScope></imprint></monogr></biblStruct><biblStruct><analytic><title level="a" type="main">Approaches to sudden death from coronary heart disease Burchell HB: Management of tachycardias associated with Wolff-Parkinson-White syndrome. 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